Inactivation of the Arf-Mdm2-p53 tumor suppressor pathway is a necessary event for tumorigenesis.Arf controls Mdm2, which in turn regulates p53, but Arf and Mdm2 also have p53-independent functions that affect tumor development.Moreover, inhibition of oncogene-induced tumorigenesis relies on Arf and p53, but the requirements of Arf and p53 in tumor
Introduction: Heroin is an extremely addictive substance, one of the most commonly abused drug worldwide.The substance derives from opium from the poppy plant before it is refined to morphine, then further chemically modified to become heroin.The different forms of heroin that are sold on the drug market can be smoked, snorted, or injected Coaxial/
Recently, most agrarian countries have witnessed either declining or stagnant crop yields.Inadequate soil organic matter (SOM) due to the poor physical, chemical, and biological properties of the soil leads to an overall decline in the productivity of farmlands.Therefore, the adoption of integrated nutrient management (INM) practices is vital to re
BACKGROUND: Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries.The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge.However, the molecular mechanism underling the hepa
This survey was done in several guava fields around Bogor and found many unhealthy plants infested by various plant pests and diseases.This study aimed to analyze the effect of various guava cultivars on pest and disease intensity on guava in the Sub-District of Tanah Sareal, Bogor.Samples were collected from 20 fields that consisted of 15 samples